Effects of a vasopressin antagonist in women with dysmenorrhea

We compared menstrual pain, uterine contractility and blood circulation, an d plasma concentrations of vasopressin and prostaglandin F-2 alpha metaboli te in women with versus without primary dysmenorrhea, and determined the ef fects of a vasopressin antagonist, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxyto cin (Atosiban), on these parameters, Our results do not support the content ion that vasopressin is involved in the etiology of dysmenorrhea, plasma co ncentrations of vasopressin being similar in dysmenorrheic women and contro ls, and the vasopressin antagonist Atosiban having no effect on menstrual p ain, intrauterine pressure or uterine artery pulsatility index in dysmenorr heic women. Copyright (C) 2000 S. Karger AG, Basel.