Autoimmune progesterone urticaria

Autoimmune progesterone dermatitis is a rare cutaneous disorder characteriz ed by recurrent and cyclic skin eruption with variable morphology, occurrin g during the luteal phase. A case of autoimmune progesterone urticaria in a 47-year-old woman is reported. An intradermal progestin test revealed a st rong reactivity against this hormone. Treatment with tamoxifen and leuproli de acetate induced only a partial remission of urticaria. Bilateral oophore ctomy was performed with absolute clearing of cutaneous lesions.