IN-VITRO ACTIVITY OF 3 CEPHALOSPORINS ALO NE OR IN ASSOCIATION WITH 2BETA-LACTAMASE INHIBITORS AGAINST 4 EXTENDED-SPECTRUM BETA-LACTAMASE-PRODUCING ENTEROBACTERIA

The in vitro antibacterial activity of cefotaxime, cefepime and cefpir ome was evaluated alone and in association with two beta-lactamase inh ibitors: clavulanic acid and sulbactam against 65 extended broad spect rum beta-lactamase producing enterobacteriaceae strains [Klebsiella pn eumoniae (35), Proteus mirabilis (9), Escherichia coli (11), Enterobac ter aerogenes (10)]. The lowest MICs were observed for cefepime and ce fpirome used alone. In association with inhibitors cefotaxime was less effective against E. aerogenes. Most isolates of K. pneumoniae, P. mi rabilis, E. coli were susceptible to all the different tested associat ions.