Solid dispersion of ketoprofen in pellets

The formulation of ternary solid dispersions of ketoprofen with Macrogol an d kollagen hydrolizate derivative as carriers was elaborated on the basis o f the results of the experiments in which different methods of solid disper sion preparation (melting, solvent method, different cooling), different co ncentrations of drug/carriers and molecular weight of Macrogol were tested. The best solid dispersion consisted of: ketoprofen-Macrogol 6000-KLHT (1 8.9 + 0.1) was chosen to formulate the pellets on the basis of the pharmac eutical availability of ketoprofen from solid dispersion and the physical c hemical studies: thermomicroscopic, DSC and X-ray diffraction. The pellets were prepared by the extrusion and spheronization method. The mechanical pr operties of the pellets as well as ketoprofen released from pellets contain ing solid dispersion, in comparison with physical mixtures and the drug alo ne, were evaluated. The increase in the amount of released ketoprofen from solid dispersion pellets was 3.8-times greater than from the pellets contai ning the drug alone. The stability of solid dispersion pellets was satisfac tory. (C) 2000 Elsevier Science B.V. All rights reserved.