Involved-field radiotherapy alone for early-stage non-small-cell lung cancer

Purpose: To describe the outcome of involved-field radiotherapy in patients with early-stage non-small-cell lung cancer (NSCLC). Methods and Materials: A written policy for the radical treatment of early- stage NSCLC with involved-field radiotherapy was adopted at our center in 1 986, The sites of known disease were treated to a dose of 52.5 Gy in 20 dai ly fractions over 4 weeks without elective irradiation of radiologically un involved regional nodes. We have reviewed the outcome of this policy in 102 patients treated with radiotherapy alone between 1986 and 1995, Results: The patients' median age was 71.5 years. The stage distribution wa s as follows: T1, 33.3%; T2, 56.9%; T3,8,8%; and T4, 1.0%, Only 5 cases wer e N1; the remainder were NO. Most patients (76.5%) were not surgical candid ates because of co-morbidity, Ninety-three percent had a CT of the thorax a s part of their initial staging, while mediastinoscopy was performed in onl y 16,7%, Overall survival was 35% at 3 years and 16% at 5 years, Recurrence free survival was 23.9% at 3 years and 13.9% at 5 years. Cause-specific su rvival was 43.5% at 3 years and 26.8% at 5 years. Of those who recurred, 68 .9% had a local component of failure at initial relapse, and 49.2% failed l ocally without evidence of regional or distant metastases, Isolated regiona l nodal relapse at initial failure occurred in only 6.6% of recurrences. Th ere were no treatment interruptions due to acute toxicity and no treatment- related deaths, Conclusion: Involved-field radiotherapy alone cures a small but significant number of patients with early-stage NSCLC. This approach is recommended in patients who are unfit for surgery and who have severely compromised pulmo nary function that would preclude the use of wide-field radiotherapy. The d ose used in this study was well tolerated, but produced suboptimal local co ntrol rates, (C) 2000 Elsevier Science Inc.