Prognostic factors that affect survival after the treatment of early stagecervical carcinoma

The aim of this study was to investigate the presence of risk factors for p redicting survival and to evaluate the efficacy of the radical surgery in p atients with early stage cervical carcinoma. A total of 200 women who under went radical hysterectomy and bilateral pelvic lymph node dissection for ea rly stage cervical carcinoma were retrospectively analysed. We found that l ymph node involvement (P <0.0015) and lymphovascular invasion (P <0.05) wer e the best prognostic factors for disease-free survival in our cases. The d epth of cervical invasion, lymphovascular invasion and parametrial spread w ere closely related with lymph node involvement. Parametrial spread was sho wn in 38 patients (19%), assessed as stage Ia-IIa pre-operatively. Seventy- six stage Ib patients, at high-risk of recurrence, received adjuvant radiot herapy. Although there was some local tumour recurrence in the control grou p, adjuvant radiotherapy did not improve the overall survival in stage Ib p atients. As a consequence, primary surgery would be definitive in estimatin g survival from histopathological evaluation. This study demonstrates that lymph node involvement and lymphovascular space infiltration were the best predictor factors for survival.