Myocardial fixation of anticardiac troponin I antibody and cardiac troponin I release

Background. The threefold aim of this experimental study was to test the co rrelation of cardiac troponin I released to myocardial infarction size and myocardial fixation of anticardiac troponin I antibody and to determine how long after myocardial infarction the measure of cardiac troponin I concent ration can evaluate myocardial infarction size. Methods. Forty rabbits mere assigned either to a control group or to an exp erimental preconditioned group. Infarction was obtained by tightening a sna re around the left anterior descending artery. Serial venous blood samples mere drawn for measurement of cardiac troponin I. The rabbits were sacrific ed at 72 hours and a histological study was performed to determine the infa rct size and the size of the area void of fixation of anticardiac troponin I antibody. Results. There was a linear correlation between the total amount of CTn I r eleased and both infarct size (r=0.45, p<0.02) and the size of the area voi d of anti-cardiac troponin I antibody (r=0.47, p<0.02), These two sizes wer e strongly correlated (r=0.95, p<0.02). The hour 9 CTn I sample was the bes t correlated with both the infarct size (r=0.47, p<0.02) and the size of ar ea void of anticardiac troponin I antibody (r=0.45, p<0.02). Conclusions. Our study shows that: 1) cardiac troponin I release is correla ted to both myocardial infarction size and the size of area void of fixatio n of anticardiac troponin I antibody, 2) the area void of anticardiac tropo nin I antibody fixation includes the whole ischemic area, and 3) evaluation of myocardial infarction size can be obtained by CTn I concentration as ea rly as the ninth hour.