Despite well-documented improvement in attention deficit hyperactivity diso
rder (ADHD) in youths with the available single and combined pharmacologic
agents, a number of youths remain with residual symptomatology causing impa
irment in multiple domains. Recent work has suggested a potential cognitive
-enhancing role of cholinergic agents in ADHD. We describe five cases of AD
HD youths aged 8-17 years being treated for ADHD with the acetylcholinester
ase inhibitor donepezil (Aricept(R)), all of whom demonstrated improvement.