RECOVERIES IN LEAD-INDUCED ALTERATIONS IN RAT-BRAIN BIOGENIC-AMINES LEVELS FOLLOWING COMBINED CHELATION-THERAPY WITH MESO 2,3-DIMERCAPTOSUCCINIC ACID AND CALCIUM DISODIUM VERSENATE

The therapeutic efficacy of meso 2,3-dimercaptosuccinic acid (DMSA) an d calcium disodium ethylenediamine tetraacetic acid (Ca disodium EDTA) either individually or during combined administration in depleting bl ood and brain lead concentration and providing recoveries in altered b rain biogenic amines levels in whole brain of rats chronically exposed to lead was determined. Adminstration of DMSA was more effective than Ca disidium EDTA in depleting brain and blood lead concentration whil e two repeated course of combined chelation therapy with DMSA and Ca d isodium EDTA (DMSA was administered twice before a single adminstratio n of Ca disodium EDTA each day) proved more beneficial than treatment with either DMSA and Ca disodium EDTA in providing recoveries in alter ed biochemical variables and reducing lead concentration from brain an d blood. The results indicate: that the combined treatment with DMSA a nd Ca disodium EDTA could be of value in providing effective and recom mended treatment for lead encephalopathy. However, still more extensiv e studies are required in this important area of lead research.