Factors influencing the clinical picture and the differential sensitization to house dust mites and storage mites

Sensitization to house dust mites and storage mites has been studied in a n umber of papers, but several environmental factors and clinical conditions that differently affect sensitization to these mites are still controversia l. The purpose of this study was to determine the influence of climatic con ditions, occupation and patient age in the differential sensitization to ho use dust and storage mites, and also to search for possible different sympt oms caused by each group of mites. Eighty patients sensitized to mites but not to other inhalant allergens were studied by case history and by skin pr ick test and serum IgE to Dermatophagoides pteronyssinus, Dermatophagoides farinae, Lepidoglyphus destructor and Tyrophagus putrescentiae. Home condit ions, including content of the allergens Der p 1, Der f 1, Lep d 2 and Tp, were determined for all patients. Human activities, such as farming or simi lar occupations, and humidity are conditions for preferential sensitization to storage mites, while we found no difference between living in rural or urban areas. Mean age for the onset of sensitization was 6.7 years for hous e dust mites and 18.7 years for storage mites. Conjunctivitis was more freq uent in patients allergic to storage mites, whereas perioral syndrome (itch ing of the tongue and swelling of the lips) was only seen in patients sensi tized to T. putrescentiae. We concluded that climatic and damp conditions a nd human activity, but not urban or rural living environments, influence th e differential sensitization to house dust mites and storage mites.