M. Ichikawa et al., The diurnal rhythm of energy expenditure differs between obese and glucose-intolerant rats and streptozotocin-induced diabetic rats, J NUTR, 130(10), 2000, pp. 2562-2567
Otsuka Long Evans Tokushima Fatty (OLETF) rats were developed as a model of
noninsulin-dependent diabetes mellitus (NIDDM) with mild obesity. Changes
in carcass composition and in the daily profile of energy expenditure were
examined before and after manifestation of diabetes (8 and 24 wk, respectiv
ely), and compared with the normal control Long Evans Tokushima (LETO) rats
and streptozotocin (STZ)-induced diabetic LETO rats. OLETF rats had greate
r body weights than LETO rats and significantly greater absolute and relati
ve fat weights. A diurnal rhythm of energy expenditure associated with two
peaks was observed in LETO rats, but the two peaks were not apparent in OLE
TF rats at 24 wk of age. A diurnal rhythm associated with one peak was obse
rved in STZ-induced diabetic LETO rats. Energy derived from fat constituted
this peak; the pattern of the daily energy expenditure was significantly d
ifferent from that of either nontreated LETO or OLETF rats at 24 wk of age.
NIDDM in OLETF rats at 24 wk of age has only a small role in modification
of the diurnal rhythm of energy expenditure, whereas STZ-induced diabetes s
ignificantly affected the rhythm.