Left brachial artery thrombus, left axillary vein thrombus, and stroke in a neonate with factor V Leiden mutation

Factor V Leiden mutation is reportedly the most common hereditary risk fact or for thrombosis. Spontaneous venous thromboses in children with factor V Leiden are rare without the presence of an additional risk factor for throm bosis. Spontaneous arterial thromboses are even more rare. Ln this case rep ort, we describe an unusual case of a neonate born with both arterial and v enous thromboses involving the left brachial artery, the left brachial vein , and stroke involving the right middle cerebral artery. The infant was sub sequently found to be heterozygous for the factor V Leiden mutation. His mo ther was also-heterozygous for the mutation but did not have a history of t hrombosis. Evaluation for the factor V Leiden mutation should form part of the work-up of an infant with either arterial or venous thromboses or strok e because it increases the infant's relative risk for future thrombosis.