A spectroscopic and crystallographic study of polymorphism in an aza-steroid

Authors
Wenslow, RM Baum, MW Ball, RG McCauley, JA Varsolona, RJ
Citation
Rm. Wenslow et al., A spectroscopic and crystallographic study of polymorphism in an aza-steroid, J PHARM SCI, 89(10), 2000, pp. 1271-1285
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN journal
00223549 → ACNP
Volume
89
Issue
10
Year of publication
2000
Pages
1271 - 1285
Database
ISI
SICI code
0022-3549(200010)89:10<1271:ASACSO>2.0.ZU;2-C
Abstract
The crystal structures of two enantiotropic polymorphs of the aza-steroid f inasteride (N-(1,1-di-methylethyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17 bet a-carboxamide) have been determined. The solid-state nuclear magnetic reson ance spectra, infrared spectra, and physical property data of these two pol ymorphs are discussed in relation to both their solid-state structures and hydrogen-bonding networks. (C) 2000 Wiley-Liss, Inc. and the American Pharm aceutical Association.