This study examined the sexual and drug use behaviors for bisexual and hete
rosexual drug users (n=11,435 males and n=5,636 females) who participated i
n the NIDA AIDS Cooperative Agreement study. Results of the study suggest t
hat, for males, bisexuality was highly associated with being homeless, havi
ng ever been paid for sex, having five or more sex partners in the month pr
eceding the interview, having an IV drug-using sexual partner in the month
preceding the interview, using crack, and sharing injection equipment in th
e month preceding the interview. For females, bisexuality was associated wi
th ever having been arrested, past substance abuse treatment, ever having b
een paid for sex, ever having paid for sex, having five or more sexual part
ners in the month preceding the interview, ever using cocaine, and sharing
injection equipment in the month preceding the interview. Overall, results
from this study indicate that both male and female bisexuals, when compared
to heterosexuals, were at higher risk for HIV and were more likely to be H
IV positive. One implication of these results is that a universal preventio
n message may not be as effective as targeting prevention messages specific
ally for bisexual males and females.