Asymmetric reduction of ketones by Geotrichum candidum in the presence of Amberlite (TM) XAD, a solid organic solvent

Authors
Nakamura, K Fujii, M Ida, Y
Citation
K. Nakamura et al., Asymmetric reduction of ketones by Geotrichum candidum in the presence of Amberlite (TM) XAD, a solid organic solvent, J CHEM S P1, (19), 2000, pp. 3205-3211
Citations number
53
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14704358 → ACNP
Issue
19
Year of publication
2000
Pages
3205 - 3211
Database
ISI
SICI code
1470-4358(2000):19<3205:AROKBG>2.0.ZU;2-L
Abstract
A hydrophobic polymer, Amberlite(TM) XAD, was used as material to control t he stereochemical course of microbial reductions. In the presence of XAD, s imple aliphatic and aromatic ketones were reduced to the corresponding (S)- alcohols in excellent enantiomreric excess (ee) while low enantioselectivit ies were observed in the absence of the polymer.