Synthesis of alpha-hydroxy-beta,beta-difluoro-gamma-ketoesters via [3,3]sigmatropic rearrangements

Readily available gamma,gamma-difluorinated allylic alcohols obtained from trifluoroethanol were esterified efficiently. Exposure to strong base (LDA) afforded the ester enolates, in which chelation both controlled configurat ion and stabilised against fragmentation, which were trapped as their silyl ketene acetals. Rearrangement occurred to afford base-sensitive acid produ cts. Esterification under mild conditions afforded the purifiable methyl es ters in which the masked ketone had been released. Educts with either a ben zyloxy or an allyloxy group at the alpha-position could be deprotected rele asing the alcohols.