Synthesis of beta-substituted alanines via Michael addition of nucleophiles to dehydroalanine derivatives

Authors
Ferreira, PMT Maia, HLS Monteiro, LS Sacramento, J Sebastiao, J
Citation
Pmt. Ferreira et al., Synthesis of beta-substituted alanines via Michael addition of nucleophiles to dehydroalanine derivatives, J CHEM S P1, (19), 2000, pp. 3317-3324
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14704358 → ACNP
Issue
19
Year of publication
2000
Pages
3317 - 3324
Database
ISI
SICI code
1470-4358(2000):19<3317:SOBAVM>2.0.ZU;2-B
Abstract
Several beta-substituted alanines are synthesised in high yields by a Micha el addition of nucleophiles to N-acyl-N-(tert-butoxycarbonyl)dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures . The same method can be applied to dipeptides containing dehydroalanine.