H. Seno et al., Parkinson's disease associated with argyrophilic grains clinically resembling progressive supranuclear palsy: an autopsy case, J NEUR SCI, 178(1), 2000, pp. 70-74
A 70-year-old male began to show akinesia, rigidity of extremities, finger
tremor, disturbed vertical external ocular movement, and nuchal dystonia, w
hich progressed slowly. Brain CT scan and magnetic resonance images showed
slight atrophy of the frontal lobe and slight enlargement of the lateral ve
ntricles. Hasegawa's dementia rating scale-revised version gave a moderate
score of 11/30 points. He died of pneumonia at the age of 76. The clinical
diagnosis was progressive supranuclear palsy (PSP). However, there were no
neuropathological characteristics of PSP. Neuropathologically, Parkinson's
disease was diagnosed. In addition, many argyrophilic grains (ArGs) in the
gray matter were stained, especially in the insula, amygdala, hippocampus,
parahippocampal gyrus, lateral occipitotemporal gyrus, and substantia nigra
, by the Gallyas-Braak method. We consider that ArGs could modify the sympt
oms of Parkinson's disease and that Parkinson's disease with ArGs may show
a PSP-like clinical course. (C) 2000 Elsevier Science B.V. All rights reser
ved.