HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein

Authors
Brandenburg, AH de Waal, L Timmerman, HH Hoogerhout, P de Swart, RL Osterhaus, ADME
Citation
Ah. Brandenburg et al., HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein, J VIROLOGY, 74(21), 2000, pp. 10240-10244
Citations number
26
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
74
Issue
21
Year of publication
2000
Pages
10240 - 10244
Database
ISI
SICI code
0022-538X(200011)74:21<10240:HCICTE>2.0.ZU;2-3
Abstract
Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clear ance of respiratory syncytial virus (RSV) infection. We have generated cyto toxic T-cell clones (TCC) from two infants who had just recovered from seve re RSV infection. These TCC were functionally characterized and used to ide ntify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.