Slow inversion of stereoisomers of cyclic GABA analogues

Authors
Gancarz, R Latajka, R Halama, A Kafarski, P
Citation
R. Gancarz et al., Slow inversion of stereoisomers of cyclic GABA analogues, MAGN RES CH, 38(10), 2000, pp. 867-871
Citations number
20
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
MAGNETIC RESONANCE IN CHEMISTRY
ISSN journal
07491581 → ACNP
Volume
38
Issue
10
Year of publication
2000
Pages
867 - 871
Database
ISI
SICI code
0749-1581(200010)38:10<867:SIOSOC>2.0.ZU;2-L
Abstract
In P-31 NMR spectra of derivatives of 1-amino- and 1w-hydroxypiperid-4-ylph osphonic acids, fully reversible conformational equilibria in aqueous and m ethanolic solutions were observed. Depending on the pH of the medium and te mperature, one or two phosphorus signals were observed indicating slow conf ormational ring interconversion under specific conditions. Copyright (C) 20 00 John Wiley & Sons, Ltd.