Purpose: The purpose of this study was to identify gender-related differenc
es in glenohumeral (GH) joint laxity, stiffness, and generalized joint hype
rmobility in healthy men and women, Methods: Fifty-one healthy men and wome
n were tested for generalized joint hypermobility, and anterior-posterior (
AP) joint laxity and stiffness using a single-group factorial design. Resul
ts: Women exhibited significantly more anterior joint laxity (men 8.3 +/- 2
.2 mm vs women 11.4 +/- 2.8 mm, P < 0.001) and less anterior joint stiffnes
s (men 20.5 +/- 5.0 N.mm(-1) vs women 16.3 +/- 4.2 N.mm(-1), P < 0.01) than
men. Men had significantly more posterior joint laxity than anterior (Ant
8.3 +/- 2.2 mm vs Post 9.6 +/- 2.9 mm; P < 0.001), and women also had signi
ficantly less anterior joint stiffness than posterior [Ant 16.3 +/- 4.2 N.m
m(-1) vs Post 22.1 +/- 6.9 N.mm(-1); P < 0.01], Women also demonstrated sig
nificantly more generalized joint hypermobility than men (men 1.0 +/- 1.7 v
s women 2.9 +/- 2.1; P = 0.02). Conclusions: Our findings may indicate a po
ssible increased risk for instability in women, especially those participat
ing in sports that require repetitive overhead-throwing motion. Future inve
stigations should seek to determine the contribution of increased GH joint
laxity and decreased joint stiffness to various injury states and examine t
hese Variables in other populations such as overhead-throwing athletes.