Long-term association of cardiovascular risk factors with impaired insulinsecretion and insulin resistance

The study aim was to investigate the association of cardiovascular risk fac tors with insulin resistance and impaired insulin secretion in an 8-year pr ospective population study in nondiabetic subjects. Cardiovascular risk fac tors of 271 subjects aged 16 to 61 years were measured at baseline, and ins ulin sensitivity and acute-phase insulin secretion were assessed by an intr avenous glucose tolerance test (IVGTT) and Bergman's minimal model 8 years later. In logistic regression analysis, baseline high-density lipoprotein ( HDL) and very-low-density lipoprotein (VLDL) cholesterol (P < .001 and P = .006, respectively), total, low-density lipoprotein (LDL), and VLDL triglyc erides (P = .004, P = .048, and P = .002, respectively), apolipoprotein Al (P = .010), and uric acid (P < .001) were associated with insulin resistanc e after adjustment for age and the body mass index (BMI). Systolic brood pr essure(P = .042) and VLDL cholesterol(P = .018) were associated with impair ed insulin secretion after adjustment for age and the BMI. This 8-year long itudinal study demonstrates that dyslipidemia, high blood pressure, and uri c acid are associated with insulin resistance, whereas high systolic blood pressure and VLDL cholesterol are associated with impaired first-phase insu lin secretion. Copyright (C) 2000 by W.B. Saunders Company.