Microwave-assisted solid-phase synthesis of cephalosporin derivatives withantibacterial activity

Authors
Kidwai, M Misra, P Bhushan, KR Saxena, RK Singh, M
Citation
M. Kidwai et al., Microwave-assisted solid-phase synthesis of cephalosporin derivatives withantibacterial activity, MONATS CHEM, 131(9), 2000, pp. 937-943
Citations number
22
Categorie Soggetti
Chemistry
Journal title
MONATSHEFTE FUR CHEMIE
ISSN journal
00269247 → ACNP
Volume
131
Issue
9
Year of publication
2000
Pages
937 - 943
Database
ISI
SICI code
0026-9247(200009)131:9<937:MSSOCD>2.0.ZU;2-V
Abstract
The reaction of heterocyclic acids with 7-amino-cephalosporanic acid adsorb ed on basic alumina under microwave irradiation afforded the N-acylated cep halosporin analogues in satisfactory yield. All compounds were tested for t heir antibacterial activity; some of them showed significant antibacterial properties. Cefotaxime and cephalothin were used as reference drugs.