The synthesis of new pyrimido[5,4-a]indolizines by reaction of 2-aminoindol
izine-1-carbonitrile or ethyl 2-aminoindolizine-1-carboxylate with various
electrophilic reagents is described. The structure of the products was conf
irmed by their elemental analysis and IR, H-1 NMR, and mass spectra. The re
sults of a preliminary antimicrobial screening are also presented.