Synthesis and hemolytic properties of arvensoside B isomers

The first partial syntheses of galactosyl-glucosyl oleanolic acid disacchar ides are described. Arvensoside B and calenduloside A, which have earlier b een isolated from Calendula arvensis and Calendula officinalis, and some fu rther oleanolic acid glycosides were prepared from differently linked aceto bromo sugars. The hemolytic properties of these saponins were investigated. Systematic variation of the carbohydrate structure and comparison with alr eady synthesized glucosyl-glucosyl analogues enable general conclusions abo ut structure-activity relationships.