During an immune response numerous receptor-mediated signals delivered to T
cells direct their proliferation, survival and differentiation. Here, we d
escribe a quantitative model and in vitro methods for assessing the "calcul
us" used by T cells to process these multiple signals, The model reveals ho
w T cells convert independently received signals into linear additive effec
ts on division times which, in turn, amplify T cell number exponentially,Th
ese results explain why so many ligands can each appear obligatory for T ce
ll activation and argue for a re-examination of the two-signal theory as th
e basis for decisions between tolerance and activation.