Mechanisms of amyloidogenesis

Authors
Kelly, JW
Citation
Jw. Kelly, Mechanisms of amyloidogenesis, NAT ST BIOL, 7(10), 2000, pp. 824-826
Citations number
9
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
7
Issue
10
Year of publication
2000
Pages
824 - 826
Database
ISI
SICI code
1072-8368(200010)7:10<824:MOA>2.0.ZU;2-0
Abstract
Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model - nucleated conformational conversion - that invokes oligomeric: inte rmediates for initiation and assembly.