Cerebellar cortical degeneration disrupts discrimination learning but not delay or trace classical eyeblink conditioning

The authors investigated classical eyeblink conditioning ina relatively rar e patient, B.R., with extensive cerebellar cortical atrophy and marked spar ing of the dentate nucleus. Patient B.R.'s ability to acquire and extinguis h simple associations (delay and trace conditioning tasks) as well as her a bility to acquire more complex associations (temporal and simple discrimina tion tasks) were examined. There are 2 primary findings from this study. Fi rst, B.R. showed normal acquisition and extinction in delay and trace condi tioning. Second, she demonstrated a complete inability to learn associative discriminations, even in the case of a simple 2-tone discrimination within the context of a delay paradigm. The latter finding was unexpected because of the sparing of her deep cerebellar nuclei. These data suggest that the cerebellar cortex, or pathways traversing cerebellar cortex, play an import ant role in classical eyeblink discrimination learning.