Gw. Rebeck, Confirmation of the genetic association of interleukin-1A with early onsetsporadic Alzheimer's disease, NEUROSCI L, 293(1), 2000, pp. 75-77
An association between altered risk of Alzheimer's disease (AD) and the int
erleukin-1A (IL-1A) gene was recently reported in two independent studies.
Here, the IL-1A polymorphism was analyzed in a third population of 247 AD ;
patients and 187 control individuals. In support of the published findings,
the IL-1A 2/2 genotype was associated with an increased risk of early onse
t AD (odds ratio of 3.1, P = 0.02). Clinically, the IL-1A 2/2 genotype was
associated with an earlier age of onset, but not with a change in the rate
of progression of AD. (C) 2000 Elsevier Science Ireland Ltd. Ail rights res
erved.