An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia
J. Ospina-duque et al., An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia, NEUROSCI L, 292(3), 2000, pp. 199-202
The short variant of a functional length polymorphism in the promoter regio
n of the serotonin transporter has been associated with several behavioural
and psychiatric traits, including bipolar mood disorder. The same short al
lele has also been implicated as a modifier of the bipolar phenotype. Here
we evaluate the etiologic/modifier role of this polymorphism in a case (N =
103)/ control (N = 112) sample for bipolar mood disorder (type I) collecte
d from an isolated South American population. We did not detect an associat
ion between bipolar disorder and the 5-HTT promoter polymorphism in this sa
mple. However, an excess of the short allele was seen in younger cases and
in cases with psychotic symptoms. When combined with data from the literatu
re, the increased frequency of the short allele in patients with psychotic
symptoms was statistically significant. (C) 2000 Elsevier Science Ireland L
td. All rights reserved.