ACTIONS OF THIENYL ANALOGS OF BACLOFEN AT GABA(B) RECEPTORS IN RAT NEOCORTICAL SLICES

Authors
ONG J KERR DIB VACCHER C BERTHELOT P
Citation
J. Ong et al., ACTIONS OF THIENYL ANALOGS OF BACLOFEN AT GABA(B) RECEPTORS IN RAT NEOCORTICAL SLICES, European journal of pharmacology, 329(2-3), 1997, pp. 133-136
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
329
Issue
2-3
Year of publication
1997
Pages
133 - 136
Database
ISI
SICI code
0014-2999(1997)329:2-3<133:AOTAOB>2.0.ZU;2-E
Abstract
In rat neocortical slices maintained Mg2+-free, Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5 -bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butano ic acid (5j) dose-dependently suppressed the spontaneous discharges, a ntagonised by the GABAB receptor antagonist 2-hydrosaclofen (200 eta M ). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These h eterocyclic analogs may prove useful as GABA(B) receptor agonist in fu nctional studies. (C) 1997 Elsevier Science B.V.