The role of positron emission tomography with fluorine-18-deoxyglucose in identifying colorectal cancer metastases to liver

Liver metastasis is a common consequence of colorectal carcinoma. Early and accurate detection of liver metastasis is crucial for a decision about par tial hepatectomy, which is considered a standard and potentially curative t herapy in such a setting. The presence of extrahepatic metastases will excl ude surgical resection as a therapeutic option. Positron emission tomograph y with fluorine-18-deoxyglucose (FDG-PET) has been successful in detecting and staging a variety of malignancies. The purpose of this study was to ass ess the utility of FDG-PET in the accurate detection of Liver and distal me tastases from colorectal cancer. The results of 80 PET and computed tomogra phy (CT) scans were compared with surgical pathology and clinical outcome. FDG-PET detected Liver metastases in 28 patients, with a sensitivity of 100 %. CT detected metastasis in 20 patients, giving a sensitivity of 71.4%. In addition, in one patient with negative CT findings, PET detected a focus o f hypermetabolism in the region adjacent to Liver, which was proven to be a second focus of primary colon carcinoma. In six patients with Liver metast ases, PET correctly detected extrahepatic lesions, while CT only detected h epatic lesions. In conclusion, FDG-PET is an excellent imaging modality for the detection and staging of Liver metastases in patients with colorectal carcinomas. ((C) 2000 Lippincott Williams & Wilkins).