In vitro MRS and HPLC studies on human renal cell carcinomas

Authors
Tosi, MR Tugnoli, V Buttura, G Lucchi, P Battaglia, A Giorgianni, P Ferri, C Mannini, D Reggiani, A
Citation
Mr. Tosi et al., In vitro MRS and HPLC studies on human renal cell carcinomas, ONCOL REP, 7(6), 2000, pp. 1355-1358
Citations number
11
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021335X → ACNP
Volume
7
Issue
6
Year of publication
2000
Pages
1355 - 1358
Database
ISI
SICI code
1021-335X(200011/12)7:6<1355:IVMAHS>2.0.ZU;2-#
Abstract
Samples from ten patients with renal cell carcinomas (RCC) were examined by H-1 MRS and high performance liquid chromatography (HPLC) measurements. Tw enty samples, ten from the tumor and ten from the surrounding healthy renal region were obtained. MRS yielded information on renal osmolytes which can be considered markers of physiological kidney function. The marked decreas e of these osmolytes is a hallmark of cancer. Moreover, HPLC measurements d isclosed the amino acid pattern of both healthy and neoplastic tissues. The Glu and Ea content had statistical significance. GSH was present in tumor tissues only.