Primary non-Hodgkin's lymphoma of the mandible treated with radiotherapy, chemotherapy, and autologous peripheral blood stem cell transplantation

Extranodal presentation in non-Hodgkin's lymphoma (NHL) is uncommon, and th e mandible is very rarely involved. Primary NHL of the mandible, for the mo st part, has intermediate or high malignancy and has a much greater inciden ce of local recurrence compared with other sites of involvement. A 48-year- old Japanese man with NHC of the mandible received radiotherapy, followed b y high-dose chemotherapy supported with peripheral blood stem cell transpla ntation (PBSCT). High-dose cyclophosphamide, Adriamycin, and vincristine we re used for pretransplant conditioning. He achieved complete remission and has survived in continuous complete remission for more than 72 months to da te. Marrow-ablative chemotherapy facilitated by PBSCT is thought to be usef ul as part of the primary therapy for patients with NHL who have poorer pro gnoses.