Reaction of 2-bromomethylazoles and TosMIC: A domino process to azolopyrimidines. Synthesis of core tricycle of the variolins alkaloids

Authors
Mendiola, J Minguez, JM Alvarez-Builla, J Vaquero, JJ
Citation
J. Mendiola et al., Reaction of 2-bromomethylazoles and TosMIC: A domino process to azolopyrimidines. Synthesis of core tricycle of the variolins alkaloids, ORG LETT, 2(21), 2000, pp. 3253-3256
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
21
Year of publication
2000
Pages
3253 - 3256
Database
ISI
SICI code
1523-7060(20001019)2:21<3253:RO2ATA>2.0.ZU;2-A
Abstract
GRAPHICS A new reaction of N protected 2-bromomethylazoles and tosylmethyl isocyanid e (TosMIC) leading to the preparation of azolopyrimidines is described. Thi s domino sequence was used to synthesize the pyrido[3',2':4,5]pyrrolo[1,2-c ]pyrimidine core of alkaloids variolins from 4-methoxy-2-methylpyrrolo[2,3- b]pyrimidine in two steps.