Factors related to outcome of salvage therapy for isolated cervical recurrence of squamous cell carcinoma in the previously treated neck: A multi-institutional study
Bj. Krol et al., Factors related to outcome of salvage therapy for isolated cervical recurrence of squamous cell carcinoma in the previously treated neck: A multi-institutional study, OTO H N SUR, 123(4), 2000, pp. 368-376
OBJECTIVE: The goal was to identify factors associated with the outcome of
salvage therapy for patients with isolated cervical recurrences of squamous
cell carcinoma in the previously treated neck (ICR-PTN).
STUDY DESIGN AND SETTINGS: A tumor registry search for ICR-PTN patients was
performed at 7 participating institutions, and the charts were reviewed. K
aplan-Meier plots for survival and time until re-recurrence were used to ev
aluate the significance of associated variables.
RESULTS: Median survival and time until re-recurrence were both 11 months.
Survival was better in patients with the following characteristics: nonsurg
ical initial neck treatment, negative initial disease resection margins, no
history of prior recurrence, ipsilateral location of the ICR-PTN relative
to the primary, and use of surgical salvage.
CONCLUSIONS: By pooling the experience of 7 US tertiary care medical center
s, we have identified 5 factors that are associated with outcome of salvage
therapy for ICR-PTN.
SIGNIFICANCE: Consideration of these factors, as well as the reviewed liter
ature, should facilitate patient selection for salvage protocols.