Cerebral aspergillosis in children - Report of three cases

Between March and December of 1997, 3 cases of infantile cerebral aspergill osis appeared in our hospital. All patients presented some kind of immunosu ppression associated with clinical findings of intracranial hypertension. A fter surgery, all cases were histopathologically confirmed and had positive cultures of Aspergillus, The first case was a patient with a history of su btotal resection of supratentorial ependymoma which presented a new enhanci ng mass on a control CT scan. Brain tumor recidiva was suspected, although, an Aspergillus granuloma was encountered on the tumor bed. Both other case s were found in patients who underwent transplantation: one presented multi ple cerebral lesions after a renal transplant, and the other, after a bone marrow transplant, developed a rhinocerebral aspergillosis, The discussion was focused on the clinical findings, images and treatment of this cerebral infectious disease. Copyright (C) 2000 S. Karger AG. Basel.