Ilio-psoas abscess is rare in neonates and is usually treated by surgical d
rainage. We report two cases of ilio-psoas abscess in 15- and 21-day-old in
fants successfully treated by US-guided percutaneous drainage as a suppleme
nt to antibiotic therapy. Clinical improvement was observed within 24-48 h
of drainage and subsequent imaging demonstrated resolution of the abscess c
avity. The analysis of these cases and of those previously reported indicat
es that imaging is essential for diagnosis. In neonates, US-guided percutan
eous drainage may represent the first-choice treatment of this disease in a
ssociation with antibiotic therapy.