Novel application of Wiener vis-a-vis Szeged indices: Antitubercular activities of quinolones

The paper gives a brief account of the recently introduced Szeged index (Sz ). Using this index antitubercular activities of N-2,4-difluorophenyl quino lones are subjected to quantitative structure-activity relationship analysi s. The potential of St related to the Wiener index (W) is critically discus sed. In addition, Huckel molecular orbital energies: E-HOMO, E-LUMO and E-t otal were also used for comparing and modelling antitubercular activities o f the quinolones. The results, based on univariate as well as multivariate regressions, have shown that W, Sz and E-total give better results and that the correlations improve in multivariate regression analyses.