H. Ishizaki et al., Role of Rab GDP dissociation inhibitor alpha in regulating plasticity of hippocampal neurotransmission, P NAS US, 97(21), 2000, pp. 11587-11592
Citations number
22
Categorie Soggetti
Multidisciplinary
Journal title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Rab CDP dissociation inhibitor alpha (Rab GDl alpha) is a regulator of the
Rab small G proteins implicated in neurotransmission, and mutations of Rab
GDl alpha cause human X-linked mental retardation associated with epileptic
seizures. In Rab GDl alpha-deficient mice, synaptic potentials in the CA1
region of the hippocampus displayed larger enhancement during repetitive st
imulation, which was apparently opposite to the phenotype of Rab3A-deficien
t mice. Furthermore, the Rab GDl alpha-deficient mice showed hypersensitivi
ty to bicuculline, an inducer of epileptic seizures. These results suggest
that Rab GDl alpha plays a specialized role in Rab3A recycling to suppress
hyperexcitability via modulation of presynaptic forms of plasticity.