The role of treatment duration in chemotherapy regimens for the treatment of malignant diseases

Background: The treatment of malignant tumors consists in the optimal combi nation of the 4 modalities surgery, radiotherapy, chemotherapy, and immunot herapy. An important goal of clinical research is the development of the op timal application of each of these modalities. Method: This review of the literature focuses on the importance of the tota l treatment duration and dose intensity in the development of chemotherapy regimens. Three important malignant diseases will be examined as to thr: op timal application of systemic chemotherapy. Result and Conclusion: Tumor models with the resulting hypotheses and well- designed clinical trials will Lead to progress in the treatment of malignan t tumors.