Background. Ampullary tumors should be resected because of the high inciden
ce of malignancy and the unreliability of preoperative endoscopic diagnosis
. Controversy exists about whether to perform a transduodenal excision (TDE
) or a pancreatoduodenectomy. This study evaluated the safety and long-term
efficacy of TDE.
Methods. The records of 21 patients with a pathologic diagnosis of ampullar
y adenoma who underwent TDE were reviewed. Demographics, symptoms, patholog
ic findings, and outcomes were analyzed and long-term follow-up was ascerta
ined.
Results. Twenty-one patients (mean age, 61 years) underwent TDE. Final path
ology showed adenoma in all patients including 1 (5%) with invasive cancer,
2 (9%) with microinvasive cancer, 6 (28%) with high-grade dysplasia, and 1
(5%) with low-grade dysplasia. The overall survival was 85% (mean follow-u
p of 38 months). One of 3 late deaths was likely related to disease progres
sion. Sixteen of the 18 remaining patients (89%) had no evidence of tumor r
ecurrence. One benign ampullary recurrence was successfully treated endosco
pically. One additional patient developed an ampullary cancer and underwent
pancreatoduodenectomy.
Conclusions. TDE of benign ampullary tumors, even those with varying grades
of dysplasia, can be per formed with acceptable morbidity and low rates of
recurrence. Postoperative endoscopic surveillance is mandatory to identify
, recurrent tumors.