alpha-silyl ketone controlled asymmetric syntheses

Enantiomerically pure alpha-silyl substituted ketones can be easily prepare d via the SAMP/RAMP hydrazone method starting from simple and cheap ketones and silylating reagents. These compounds are very useful precursors for th e regio- and stereoselective formation of carbon-carbon and carbon-heteroat om bonds with very high asymmetric inductions in many cases. A great variet y of important organic reactions using alpha-silyl ketones as well as alpha -silyl aldehydes and their application for the synthesis of bioactive compo unds are presented.