Dihydroxyverbacine is the terminal precursor in the biosynthesis of aphelandrine and orantine

Authors
Nezbedova, L Hesse, M Drandarov, K Werner, C
Citation
L. Nezbedova et al., Dihydroxyverbacine is the terminal precursor in the biosynthesis of aphelandrine and orantine, TETRAHEDR L, 41(41), 2000, pp. 7859-7862
Citations number
13
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
41
Year of publication
2000
Pages
7859 - 7862
Database
ISI
SICI code
0040-4039(20001007)41:41<7859:DITTPI>2.0.ZU;2-3
Abstract
A microsomal-bond cytochrome P-450 enzyme system has been discovered in the roots of Aphelandra squarrosa that is responsible for the stereospecific i ntramolecular phenol coupling of (S)-dihydroxy-verbacine to aphelandrine. T he biogenesis of the closely related alkaloids orantine (ephedradine A) and ephedradines B, C and D should follow a similar biogenetic pattern. (C) 20 00 Elsevier Science Ltd. All rights reserved.