Microwave-assisted solvent-free parallel synthesis of thioamides

Authors
Olsson, R Hansen, HC Andersson, CM
Citation
R. Olsson et al., Microwave-assisted solvent-free parallel synthesis of thioamides, TETRAHEDR L, 41(41), 2000, pp. 7947-7950
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
41
Year of publication
2000
Pages
7947 - 7950
Database
ISI
SICI code
0040-4039(20001007)41:41<7947:MSPSOT>2.0.ZU;2-H
Abstract
Rapid parallel synthesis of thioamides is described. A library of amides, s ynthesised by mixing acyl chlorides and diamines, was transformed into the corresponding thioamides utilising Lawesson's reagent as the oxygen/sulphur exchange reagent. Purification by solid-phase extraction afforded the libr ary members in adequate purities and yields. (C) 2000 Elsevier Science Ltd. All rights reserved.