Synthesis of phenylacetic acids under rhodium-catalyzed carbonylation conditions

Authors
Giroux, A Nadeau, C Han, YX
Citation
A. Giroux et al., Synthesis of phenylacetic acids under rhodium-catalyzed carbonylation conditions, TETRAHEDR L, 41(40), 2000, pp. 7601-7604
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
40
Year of publication
2000
Pages
7601 - 7604
Database
ISI
SICI code
0040-4039(20000930)41:40<7601:SOPAUR>2.0.ZU;2-J
Abstract
Benzyl halides are efficiently carbonylated to phenylacetic acids in the pr esence of a catalytic amount of the dimer of chloro(1,5-cyclooctadiene)rhod ium(I) in formic acid. Under these reaction conditions, sensitive functiona lities such as esters and nitriles are tolerated and the phenylacetic acids are obtained in good to high yields. (C) 2000 Elsevier Science Ltd. All ri ghts reserved.