A novel highly stereoselective total synthesis of epothilone B and of its (12R,13R) acetonide

Authors
Mulzer, J Karig, G Pojarliev, P
Citation
J. Mulzer et al., A novel highly stereoselective total synthesis of epothilone B and of its (12R,13R) acetonide, TETRAHEDR L, 41(40), 2000, pp. 7635-7638
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
40
Year of publication
2000
Pages
7635 - 7638
Database
ISI
SICI code
0040-4039(20000930)41:40<7635:ANHSTS>2.0.ZU;2-G
Abstract
Stereoselective syntheses of epothilone B (1) and its novel derivative 2 ar e described. Key steps are the formation of intermediate 3 via Sharpless AD -reaction and Davis-Evans-hydroxylation. (C) 2000 Elsevier Science Ltd. All rights reserved.