Citation
W. Yao et al., Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides, TETRAHEDR L, 41(40), 2000, pp. 7711-7715
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039
→ ACNP
Volume
41
Issue
40
Year of publication
2000
Pages
7711 - 7715
Database
ISI
SICI code
0040-4039(20000930)41:40<7711:NAHEDP>2.0.ZU;2-7
Abstract
A series of novel hydroperoxides of heterocyclic-fused naphthalimides were
designed, synthesized and exhibited excellent DNA photonicking activities.
Among these compounds, the benzothiophenonaphthalimide-type reagent proved
to be the most efficient, it can induce single-strand nicks in duplex DNA a
t micromolar concentration upon illumination. The relationship between the
molecular structure and cleaving activities was discussed. (C) 2000 Elsevie
r Science Ltd. All rights reserved.