Enzymic resolution of an alpha-methylene-gamma-lactonic ester

Authors
Pitacco, G Santi, ASO Valentin, E
Citation
G. Pitacco et al., Enzymic resolution of an alpha-methylene-gamma-lactonic ester, TETRAHEDR-A, 11(16), 2000, pp. 3263-3267
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
16
Year of publication
2000
Pages
3263 - 3267
Database
ISI
SICI code
0957-4166(20000825)11:16<3263:EROAAE>2.0.ZU;2-7
Abstract
The possibility of using enzymes for the kinetic resolution of an alpha-met hylene-gamma-lactone was explored. The probe molecule, ethyl 2-methyl-4-met hylene-tetrahydro-5-oxo-2-furancarboxylate was successfully resolved with P orcine pancreatic lipase and Candida rugosa lipase, in the presence of a co solvent, leading to both enantiomers of the corresponding acid with high en antiomeric excesses. (C) 2000 Elsevier Science Ltd. All rights reserved.