Progression of an orbital T-cell rich B-cell lymphoma to a B-cell lymphomain a dog

Citation
Sm. Aquino et al., Progression of an orbital T-cell rich B-cell lymphoma to a B-cell lymphomain a dog, VET PATH, 37(5), 2000, pp. 465-469
Citations number
22
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
Journal title
VETERINARY PATHOLOGY
ISSN journal
03009858 → ACNP
Volume
37
Issue
5
Year of publication
2000
Pages
465 - 469
Database
ISI
SICI code
0300-9858(200009)37:5<465:POAOTR>2.0.ZU;2-2
Abstract
An 11-year-old Shetland Sheepdog was presented for exophthalmos caused by a locally extensive, poorly defined mass located behind the right eye. The p rimary orbital mass was identified by light microscopy and immunohistochemi stry as a T-cell rich B-cell lymphoma (TCRBCL) composed predominantly of BL A.36-positive large neoplastic lymphoid cells admired with fewer CD3- and C D79a-positive small lymphocytes. The dog was treated fur lymphoma, but 6 mo nths after presentation it was euthanatized for suspected hepatic and gastr ointestinal metastasis. Gross findings revealed an enlarged liver with mult iple well-demarcated, randomly distributed 0.1-1.5-cm white nodules, five f irm white submucosal jejunal nodules, and ileocecal, mediastinal, and hilar lymphadenopathy. Metastatic liver lesions consisted of sheets of monomorph ic large neoplastic lymphoid cells that effaced and expanded por tal and ce ntrilobular zones. These cells were morphologically similar to the large ne oplastic cells of the original orbital tumor and were CD3-negative and vari ably BLA.36-positive, consistent with B-cell lineage. Similar cells compris ed the jejunal nodules and effaced the lymph nodes. The progression of TCRB CL to a diffuse B-cell lymphoma in this case is consistent with reported hu man cases and has not been previously reported in the dog.